Rad As a Novel Regulator of Excitation–Contraction Coupling and -Adrenergic Signaling in Heart
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چکیده
sarcoplasmic reticulum release. Conversely, 70% Rad knockdown by RNA interference increased ICa (50%), [Ca ]i transients (52%) and contractility (58%) without altering EC coupling efficiency; and the dominant negative mutant RadS105N exerted a similar effect on ICa. Rad upregulation caused depolarizing shift of LCC activation and hastened time-dependent LCC inactivation; Rad downregulation, however, failed to alter these
منابع مشابه
Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart.
RATIONALE Rad (Ras associated with diabetes) GTPase, a monomeric small G protein, binds to Ca(v)beta subunit of the L-type Ca(2+) channel (LCC) and thereby regulates LCC trafficking and activity. Emerging evidence suggests that Rad is an important player in cardiac arrhythmogenesis and hypertrophic remodeling. However, whether and how Rad involves in the regulation of excitation-contraction (EC...
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